Symptom & Goal

Is HIIT Good for Perimenopause Brain Fog?

Discover how HIIT boosts BDNF and cognitive function during perimenopause, helping clear brain fog through targeted interval training.

5 min readFebruary 28, 2026

Brain Fog and the Perimenopausal Brain

Brain fog is one of the most disorienting symptoms of perimenopause. Women describe it as forgetting words mid-sentence, walking into a room with no idea why, struggling to concentrate in meetings, and feeling as though a mental haze has settled over thinking that used to be sharp. Research now confirms this is not anxiety or overwork. It is a neurological response to falling oestrogen levels. Oestrogen plays a significant role in brain function. It supports the production and activity of neurotransmitters including serotonin, dopamine, and acetylcholine, and it promotes neuroplasticity, the brain's ability to form new connections. As oestrogen fluctuates and declines during perimenopause, memory, verbal recall, and processing speed are genuinely affected. The good news is that the brain retains substantial plasticity, and exercise, particularly high-intensity exercise, is one of the most potent stimulants of brain health available without a prescription.

BDNF: The Brain Fertiliser That HIIT Produces

Brain-derived neurotrophic factor, commonly abbreviated to BDNF, is a protein that supports the survival and growth of neurons and promotes the formation of new synaptic connections. It is sometimes called brain fertiliser because of its role in cognitive function, learning, and memory. BDNF levels naturally decline with age, and research suggests that falling oestrogen during perimenopause further reduces BDNF activity, contributing directly to brain fog symptoms. High-intensity exercise is one of the most effective ways to raise BDNF. Studies consistently show that intense aerobic activity produces a significantly greater spike in BDNF than moderate exercise. A 2021 review in Frontiers in Physiology found that HIIT was particularly effective at increasing BDNF levels, with effects observed even from short sessions of 15 to 20 minutes. For perimenopausal women seeking cognitive support, this makes HIIT a compelling option.

Additional Brain Benefits of HIIT

Beyond BDNF, HIIT improves brain health through several other pathways. It increases cerebral blood flow, delivering more oxygen and glucose to brain tissue. It promotes neurogenesis, the formation of new neurons, particularly in the hippocampus, the region most involved in memory and learning. It reduces neuroinflammation, which is increasingly recognised as a contributor to cognitive decline. HIIT also improves sleep quality over time, and sleep is when the brain consolidates memories and clears metabolic waste products through the glymphatic system. Women who find that night sweats or insomnia are worsening their brain fog can find that regular HIIT, by improving sleep architecture, provides cognitive benefits through this indirect route as well. The cumulative effect of these mechanisms means that the brain benefits of HIIT extend well beyond the workout itself.

Timing and Type of HIIT for Cognitive Benefits

Aerobic HIIT, meaning interval training that raises heart rate significantly, produces more BDNF than resistance-based circuit training, though both have cognitive benefits. If brain fog is a primary concern, prioritise aerobic intervals such as cycling, rowing, running, or fast walking on an incline. Morning sessions may offer an advantage for cognitive function, as the BDNF and catecholamine spike in the hours following exercise can support mental clarity through the working day. That said, exercise done at any time of day is beneficial. Avoid intense HIIT within two to three hours of bedtime if sleep disruption is already a problem, as the stimulating effect may make it harder to fall asleep. Two to three HIIT sessions per week is a practical frequency that provides cognitive benefits without excessive physical stress.

Low-Impact Options When Joints Are Sensitive

High-impact HIIT such as jumping, sprinting, and plyometric exercises can aggravate joints, and joint pain is a common perimenopause symptom due to declining oestrogen's effect on cartilage and connective tissue. The cognitive benefits of HIIT do not require high impact. A stationary bike with sprint intervals, a rowing machine, an elliptical trainer, or incline treadmill walking at high effort all achieve the heart rate elevations needed to trigger BDNF release. Swimming is another excellent option, as the resistance of water creates significant cardiovascular demand without joint loading. The key measurement is internal effort. If your perceived exertion during the work intervals is seven or eight out of ten and you could not sustain it for more than a minute or two, you are in the intensity range that drives the neurological adaptations you are looking for.

Supporting HIIT with Brain-Healthy Habits

HIIT works best for brain fog when combined with other brain-supportive habits. Adequate sleep is the most important. Prioritising seven to nine hours and addressing night sweats, whether through cooling measures, bedding choices, or discussing hormone therapy with your GP, will amplify the cognitive benefits of exercise. Nutrition also matters. Omega-3 fatty acids, found in oily fish, walnuts, and flaxseed, are essential for neuronal membrane integrity and reduce neuroinflammation. Magnesium supports nerve function and helps regulate sleep. Minimising alcohol is particularly relevant because alcohol disrupts sleep architecture and directly impairs BDNF production. Cognitive engagement through reading, learning new skills, and social connection also supports the neuroplasticity that HIIT promotes, creating a compounding effect on brain resilience.

What to Expect Over Time

Brain fog does not lift overnight, and it is worth knowing that cognitive changes during perimenopause are typically temporary. Research from the Study of Women's Health Across the Nation found that most women's cognitive function returned to baseline or better in the post-menopausal years. Exercise, and HIIT in particular, helps you navigate this transitional period with more mental clarity. Many women report noticing improved concentration and sharper thinking within four to eight weeks of beginning a consistent HIIT programme. The improvements tend to build gradually. Consistency matters far more than intensity. Three short HIIT sessions per week maintained for months will produce meaningfully better cognitive outcomes than occasional intense efforts separated by long gaps. Think of HIIT for brain fog as a long-term investment in the health of the organ you most need to function well.

Related reading

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Medical disclaimerThis content is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about a medical condition. PeriPlan is not a substitute for professional medical advice. If you are experiencing severe or concerning symptoms, please contact your doctor or emergency services immediately.

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