Does red clover help with mood swings during perimenopause?

Red clover shows some evidence of supporting mood during perimenopause, primarily as a secondary benefit alongside its better-established effects on vasomotor symptoms. The connection involves how phytoestrogens interact with estrogen-sensitive areas of the brain.

What red clover contains and how it may affect mood

Red clover (Trifolium pratense) is rich in phytoestrogenic isoflavones: formononetin, biochanin A, daidzein, and genistein. These compounds bind to estrogen receptor beta (ER-beta), which is found in the limbic system, the brain region most closely associated with emotional regulation. Estrogen normally modulates serotonin, dopamine, and norepinephrine pathways in this area. When estrogen levels fluctuate unpredictably during perimenopause, the resulting neurochemical instability can contribute to mood swings, irritability, and emotional reactivity.

By providing a low-level, consistent estrogenic signal through ER-beta, red clover isoflavones may help dampen some of the neurochemical volatility that drives mood instability.

What the research shows

Hidalgo et al. (2005) conducted a randomized controlled trial of red clover isoflavones at 80mg per day and found a 44% reduction in hot flash frequency. Mood improvement was reported as a secondary outcome by participants in the active treatment group. Chedraui et al. (2008) found a significant reduction in the overall Kupperman symptom index, which includes measures of anxiety, depression, and irritability as component items. This suggests that red clover may improve the overall perimenopausal symptom burden, with mood benefits as part of that broader picture.

Lipovac et al. (2012) found improved quality of life scores in women taking red clover isoflavones, and quality of life assessments in perimenopausal populations typically capture mood and emotional wellbeing as key domains.

It is worth noting that none of these studies used mood as a primary outcome measure, so the evidence is supportive rather than definitive.

Important safety information

If you have or have had a hormone-sensitive condition such as breast cancer, endometriosis, or uterine fibroids, discuss red clover with your healthcare provider before using it.

Red clover contains coumarin compounds and may mildly reduce blood clotting. Women taking anticoagulants such as warfarin should discuss this with their provider. Interactions with tamoxifen and other hormonal medications are also a concern.

Studies have generally used 40mg to 80mg of red clover isoflavones per day. Talk to your healthcare provider about the right dose for your situation.

Tracking your response

Mood swings during perimenopause are influenced by hormonal shifts, sleep quality, stress, and life circumstances simultaneously. To understand whether red clover is making a difference, track your mood daily using PeriPlan before starting and throughout your supplement trial. Look for changes in the frequency or intensity of mood swings over a 6 to 8 week period. Patterns across weeks are more meaningful than any single day.

Considering the multi-factorial nature of mood dysregulation in perimenopause, combining red clover with evidence-based lifestyle strategies is a reasonable approach. Regular aerobic exercise has well-established mood-stabilizing effects. Consistent sleep schedules reduce the hormonal disruption that amplifies emotional reactivity. Stress reduction practices such as mindfulness or therapy address the psychological contributors directly.

When to see a doctor

If mood swings are severe, interfering with daily functioning, or accompanied by persistent low mood, loss of interest, hopelessness, or thoughts of self-harm, seek evaluation from your healthcare provider or a mental health professional promptly. Perimenopausal mood changes can overlap with clinical depression and anxiety disorders, which benefit from specific treatments beyond supplementation. Your provider can help distinguish between hormone-related mood changes and conditions that require dedicated mental health care.

This content is for informational purposes only and does not replace medical advice. Always consult your healthcare provider about your specific situation.